After their mother's death, four brothers are reunited. Wayne is a gunman; Anderson is a college graduate; silent Holliman is a killer; and Martin is a gambler. When they learn that her death might have been linked to their father's murder, they come together to devise a way to seek revenge on the killer. The town bullies complicate matters; the sheriff tells them to lay off. Especially strong screen presence by Wayne, in his first role following cancer surgery. One of the Duke's most popular movies of the '60s.