Married biotech scientists Sorvino and Northam upset the balance of nature when they cure a plague only to have their insectoid concoction unleashed in the New York subways. This causes giant cockroaches to mimic--and kill--humans. Far-fetched story is forgiven with a unique script (both John Sayles and Steven Soderbergh made additions) and original kills and thrills. Plenty of gore also makes it a worthy addition to the horror genre.